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AU400 Clinical Chemistry Analyzer

by Olympus Diagnostics


Outstanding performance

The new AU 400system is a fully automated, random access clinical chemistry analyser with all the benefits of Olympus Systems Compatibility.


With a throughput of 400 photometric tests per hour the system provides high performance analysis, including STAT and ISE capability, in a compact package for small and medium size laboratories.

Technology and innovation

Outstanding engineering includes the unique Spot Photometry measurement system that uses data in digital format and transmission through fibre opticsto eliminate electromagnetic interference and signaldrift.


Improved measurement enables reduced reaction volumes and delivers savings in reagent and running costs.

Easy software

Multiple module control with 32 bit RISC chips ensures precise control with high throughput. Ease ofoperation is assured with mouse control Windows software and touch screen.  


Afull range of Olympus System Reagents developed in tandem with the analyser range provides optimised measurement for routine and specialist tests.

Technology and innovation

The AU 400 analyser system stands out due to theeconomy and high efficiency of a Random-Access Systemcombined with effort-saving handling and an exceptional reliability:


  • Minimised consumption of liquid stable reagents

  • Reaction volume down to 150 μl

  • Throughput of 800 tests per hour with ISE



  • Spot photometry system gives unrivalled accuracy

  • Interference-free fibre optic data transfer


Easy of use

  • Bar-coded reagents and primary cups for routine and STAT samples

  • GUI menus and user definable routines in Windows NT®software



  • Overall flexibility: The AU 400 combines flexible analysis withs ophisticated control and measurement reliability. 

  • STAT samples can be quickly processed at any time. Barcoded primary tubes or special sample cups are placed in a distinguished STAT rotor with 22 positions. 

  • Optimized technologies: Computer controlled liquid dispensing provides speed and positional adjustment. Probe tip speed control prevents liquid splashing. Probe depth automatically adjusts to match the dispensed volume. Safety features include clot detection and crash prevention.

  • Safety features include clot detection and crash prevention.

  • Volume variation ofresults is minimized andmore accurate measurementis provided on reactionvolumes as little as 150 μl. 

  • Contamination is eliminated with a triple washing station. Cuvettes are washed with detergent twice and rinsed with purified water four times in each cycle. Time for mixing and cleaning steps has been reduced to 4.5 seconds.

  • Windows NT®basedsoftware: The latest software across the range of Olympus analysers provides easy touse Windows-based mouse control. Pull down menus and help functions ensurethat basic operation can be mastered within minutes. Modem support for continuous communication and service is provided.



An expanding range of reagents Olympus liquid stable reagents are developed in tandem with the company’s range of clinical chemistry analysers. Formula, concentration and packaging are perfectly matched to the AU400.


The TRIS automatic identification barcoding system includes batch and expiry details to meet laboratory procedural requirements. Reagent vials of either 15 ml, 30 ml or 60 ml vol-ume featuring long on-board stability. 


Over 80 tests are available including Substrates, Enzymes, Specific Proteins, DAU, TDM and Homogeneous Immuno Assays.


Compatibility acrossall systems

Major savings incosts, logistics, storage space and efficiency are delivered by using the same reagents across Olympus systems, even in complex laboratory settings 


Olympus flexible racks are designed for all primary tubes in the range of 11.5 mm – 16 mm diameter. 

The AU400 has the family hardware and software, and uses the same reagents, as the larger AU 600, AU640, AU2700, AU480, AU680, AU2700 PLUS, AU5400 and AU5800 analysers.



Application consultancy: We provide help for requests concerning reagents or on how to conduct tests through our application specialists. Incases where an application problem cannot be solved over the telephone, we give direct assistance in your laboratory. Operator training Our specialists will teach you all the necessary basic knowledge about operation, application and user maintenance. In addition customised on-site training is of course available. Delivery service Your order is handled by us immediately.  

Technical equipment service: Our support team of field based engineers and specialists is further enhanced by expert telephone assistance from a specialist who can provide immediate advice on technical problems and how to get the best out of your Olympus system.Individual laboratory and contract concepts The sales representative, assigned to you, willstructure made-to-measure system solutions for you.


AU 400 Specifications

Analytical system

Fully automated, for routine, STAT, urine and homogeneous Immuno Assays

Analytical methods

Clinical chemistry and immunological parameters. End point, kinetic assays,

fixed-time-kinetics, optionally ISE

Simultaneously processed analytes

Up to 51 photometric tests + 3 ISE


400 photometric tests / hour; maximum of 800 with ISE

Sample feeder

Racks with 10 samples each (bar-codes on primary tubes and on racks);

capacity of 80 samples; continuous loading

Sample tubes

In primary and secondary tubes; diameter from 11.5 to 16 mm;

height from 55 to 102 mm

STAT samples

Up to 22 positions for STAT samples, bar-coded primary tubes

Sample volume

2 – 50 μl in 1 μl steps (1– 50 μl for repeats)

Reagent supply

Refrigerated (4° C – 12° C); 76 positions for R1 / R2

Reagent volume

1. reagent: 25 – 300 μl; 2. reagent: 25 – 300 μl; (in 1 μl steps)

Total reaction volume

150 – 550 μl

Reaction cuvette

Quartz cuvettes

Reaction time

Up to 8 minutes, 40 seconds

Reaction temperature

37° C

Mixing method

With rotating paddles after dispensing sample and reagent

Photometry system

Direct assay through the reaction cuvette (0 – 2.5 OD) mono-, bichromatic

measurements possible

Wave length

13 different wave lengths between 340 – 800 nm

Cuvette cleaning

Comprehensive cleaning with detergents


Linear and non linear (linear interpolation), refrigerated calibrator positions

Data processing

Calculated parameters, blank value correction and correlation. Definition of normal

value range, measuring range, pathological values and repeats. Quality controls,

printout of abnormal values, pending sample work list and repeat run sample list

Test requisition

Individual and profile test requisition via on-line, mouse, function keys or optional

touch screen


Clot detection and crash prevention for sample and reagent dispenser


Full uni- and bidirectional communication possible




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